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KMID : 0811720130170050405
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Korean Journal of Physiology & Pharmacology
2013 Volume.17 No. 5 p.405 ~ p.409
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Sex Differences in Hippocampal Neuronal Sensitization by Nicotine in M. gerbils
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Hur Young-Na
Lee Joon
Sohn Seung-Chan
Won Chung-Gil
Lee Hyung-Ha
Kim Dong-Hoon
Choi Sang-Hyun
Shin Kyung-Ho
Chun Boe-Gwun
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Abstract
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We studied the sex different nicotine effect on evoked population spike amplitudes (ePSA) and connexin (Cx) expression in the hippocampus CA1 area of gerbils. Acute doses of nicotine bitartrate (0.5 mg/kg: NT-0.5) slightly reduced ePSA in males but markedly augmented that in females. Acute NT (5.0 mg/kg) markedly increased the ePSA in all gerbils. Unlike acute NT-0.5, repeated NT-0.5 injection (twice a day for 7 days) significantly increased the ePSA in males and slightly affected the NT-0.5 effect in females. The Cx36 and Cx43 expression levels as well as Cx expressing neuronal populations were significantly increased by repeated NT-0.5 in in both male and female gerbils, and particularly, Cx43 expression was somewhat prominent in females. These results demonstrated a sex difference with respect to the nicotine effect on hippocampal bisynaptic excitability, irrelevant to connexin expression.
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KEYWORD
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Connexin, Evoked population spike, Hippocampus, Nicotine, Sex difference
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